Research · Neuroscience · Safety
Follow developments in nootropics and brain research with their sources and limitations. We explain what a new finding says, and what it cannot establish.
128 published articles
Research
In 82 people with isolated REM sleep behavior disorder, a five-week digital cognitive-training and lifestyle-guidance program was linked to modest executive-function gains versus a waiting-list group.
neuroscience
A new two-photon system stimulated selected mouse neurons across a millimetre-scale field while imaging downstream responses. It supports circuit experiments across areas; it remains a specialized research tool, not a human application.
Research
In an open randomized study of 54 people starting device-aided Parkinson therapy, tailored rehabilitation was linked to better cognitive performance at one year, a secondary finding needing confirmation.
Research
In 116 adults, an energy drink did not outperform a beverage matched for 200 mg caffeine on attention or memory after one acute test session.
neuroscience
In Alzheimer’s-model mice and postmortem human tissue, researchers identified mitochondrial accumulations in neuronal processes alongside impaired lysosomal clearance. The finding describes pathology; it does not establish a treatment or cognitive effect.
neuroscience
Recordings in macaques found that sleep reactivation differed for new, recent and older learned sequences; older memories formed more stable, interconnected assemblies. The cross-sectional primate study cannot track individual cells changing over time.
Research
In 43 healthy women, working memory and attention improved over time in both groups, with no significant cognitive advantage for 16:8 time-restricted eating over usual diet.
Research
In a six-month pilot with 54 people with mild-to-moderate cognitive impairment, GeNeurofil was associated with improved test scores and lower plasma markers; the authors call for larger confirmatory trials.
Research
In a six-month assessor-blinded trial of 60 people receiving standard Alzheimer’s care, the combined intervention group had a mean MMSE increase while control scores declined. The design cannot separate diet from fasting.
Research
A staged study of 108 long-term-care residents found nutritional and cognitive measures improved mainly in the most undernourished group after tailored food support. The design cannot show that AI itself caused the changes.
neuroscience
During sleep, trained mice replayed dorsal-striatal activity sequences linked to procedural experience even after hippocampal lesions. Replay predicted later task gains, but selectively disrupting replay is still needed to establish its causal role.
Research
A 29-trial network review found mixed signals across cognitive tests in Alzheimer’s disease and mild cognitive impairment; no supplement significantly improved ADAS-Cog.