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Study design

This assessor-blinded randomized trial enrolled 60 adults aged 55–85 with early-to-mid-stage Alzheimer’s disease. Thirty received standard care plus a plant-rich ketogenic diet and intermittent fasting; 30 received standard care. Cognition and brain structure were assessed over six months.

Findings

The mean Mini-Mental State Examination score rose by 0.9 points in the combined-intervention group and fell by 1.5 in controls; change scores differed between groups (p<0.001). Reliable Change Index analysis classified 93% of the intervention group and 70% of controls as stable. The trial tests the combined program on top of standard care; it cannot separate fasting from diet.

Limitations and disclosures

The sample was small and follow-up short for a progressive disease. The abstract gives limited information on adherence, nutritional safety and broader clinical outcomes. The authors declared no competing interests. The result does not show that either diet or fasting alone reverses Alzheimer’s disease; larger studies with safety monitoring are needed.

This sourced news summary and translation were prepared with AI assistance. Source links, the news date and research limitations are disclosed; this is not a claim of independent medical expert review. News production method.

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