Research · Neuroscience · Safety
Follow developments in nootropics and brain research with their sources and limitations. We explain what a new finding says, and what it cannot establish.
128 published articles
neuroscience
In a human fMRI and eye-tracking visual-search task, more distinct hippocampal memory patterns were associated with more accurate memory-guided eye movements and less competitor activation.
Safety
SUPPLX voluntarily recalled Business Pill and Branch Manager for Men after testing identified undeclared yohimbine; FDA posted the notice on September 4.
Research
In a 33-person randomized trial, two weeks of cerebellar rTMS was followed by better global cognition than sham through week 12. fNIRS changes were hemodynamic measures, not direct recordings of neural activity.
Research
A cross-sectional analysis of 88,889 SHARE interviews associated sleep of at least 10 hours and daytime napping with lower cognition; it cannot establish whether sleep patterns cause impairment.
neuroscience
In mice learning a timing task, structured early examples supported more flexible later strategies and task-related entorhinal activity; the study also tested predictions from a neural-network model.
Research
In a prospective cohort, 42 of 449 biomarker-positive Parkinson’s participants met Alzheimer’s biomarker criteria and later showed greater cognitive and motor decline. The observational result is prognostic, not causal.
neuroscience
Experiments on mouse interneuron synapses found that lower glutamate exposure changed AMPA receptor properties through the occupancy of different conductance states.
neuroscience
Mesoscopic imaging of thousands of mouse neurons found that medial parietal areas AM and A represented visual/choice information and choice history/posture differently. The study maps functional organization; it does not establish that these areas alone cause the behaviors.
Research
An NIH-reported mouse study found late-life semaglutide improved spatial memory measures; clinical relevance to people has not been established.
Research
A study of 121 young adults with first-episode depression and 117 controls found differences across bacterial, viral, fungal and archaeal signals. Its cross-sectional design cannot establish that microbiome changes cause depression or cognitive differences.
neuroscience
A validated effective-connectivity framework inferred a human cortical hierarchy that flattened during externally focused processing and steepened during internally focused states.
Research
A multicenter analysis of recordings from people with movement disorders tested whether a generative model could infer subcortical activity from cortical signals to help address gaps in closed-loop stimulation data.