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Study design
This open-label randomized trial assigned 30 adults aged 60–80 with memory complaints and cardiovascular risk factors to consume 42–86 g/day of peanuts and peanut butter or avoid peanuts for 12 weeks. Twenty-seven participants were analyzed (12 peanut, 15 control). Measures included fMRI during a working-memory task, cognitive tests and blood biomarkers.
Findings
No significant between-group differences were found in task-related brain activation or cognitive performance. Biomarker differences that appeared in unadjusted analyses did not remain significant after multiple-comparison correction. The small trial therefore did not find evidence of a cognitive or brain-activation benefit over 12 weeks.
Limitations and disclosures
The analyzed sample was small, treatment was open-label and the intervention supplied a substantial daily amount of peanuts. The Peanut Institute funded the study and had no role in its conduct or reporting and no access to data, according to the paper. Authors reported no commercial or financial conflicts.
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