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Study design

This multicentre, double-blind trial randomized people with Parkinson’s disease and gait disturbance to ten sessions of trans-spinal theta-burst magnetic stimulation or sham; both groups had treadmill training. Seventy participants entered the modified intention-to-treat analysis and were followed for 90 days.

What it found

The active group had a greater fast-gait-speed change three days after treatment, but it did not persist. Freezing-of-gait scores differed at 30 days. After correction for multiple comparisons, only the early gait-speed and 30-day freezing findings remained significant; authors called the results hypothesis-generating.

Limits and interpretation

The trial measured gait and mobility, not memory or cognition. Follow-up was short and most outcomes did not show confirmed differences after correction. The findings do not establish lasting benefit or a change in Parkinson’s disease progression.

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Sources

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