neuroscience
Sleep-time noise disrupted hippocampal memory signals in rats
In sleeping rats, brief sounds timed to hippocampal sharp-wave ripples reduced ripple activity and disrupted retention in one memory task, while effects varied by task.
Research · Neuroscience · Safety
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Follow developments in nootropics and brain research with their sources and limitations. We explain what a new finding says, and what it cannot establish.
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128 published articles
Research
A regional brain-age pattern linked a blood tau marker with cognition
A cross-sectional analysis of 71 older adults found an indirect p-tau217–cognition association through one MRI brain-age pattern; direct and total associations were not significant.
Research
Fortified corn flour did not improve cognitive scores in a trial of Ethiopian teenage girls
A six-month trial of 472 girls found no significant cognitive benefit from folate- and B12-fortified corn flour; a language-test difference appeared in a secondary analysis by stunting status.
Research
Higher ultra-processed food intake linked to poorer attention in an Australian cohort
A cross-sectional analysis of 2,192 Australian adults associated a greater ultra-processed-food share with a slightly lower attention score, but found no clear memory link and cannot establish causation.
Regulation
FDA cites Alzheimer’s and anxiety claims on one green tea seller’s site
A July 2 FDA letter challenged a seller’s Alzheimer’s, Parkinson’s and anxiety claims for green tea; the action concerns marketing and drug approval, not a new efficacy trial.
Research
MCT-derived ketones were studied as an alternative brain fuel during hypoglycemia
A small human study found that four weeks of an MCT diet was associated with better working-memory accuracy during induced hypoglycemia in type 1 diabetes; reaction time did not improve.
neuroscience
Hippocampal theta sweeps tracked remembered goals in rats
In rats navigating an open arena, learning-dependent hippocampal theta sequences predicted routes to remembered goals and coordinated with prefrontal activity. This identifies a candidate planning circuit, not proof that the sequences cause navigation.
Research
Midlife Alzheimer’s blood markers linked with cognitive scores in cohort
A July NIH report highlighted a CARDIA cohort study linking blood amyloid and tau markers with midlife cognitive differences; the results are observational.