On this page

Study design

Researchers followed 87 people with early relapsing-remitting multiple sclerosis from diagnosis. They measured paramagnetic rim lesions and choroid plexus volume on 3-tesla MRI and assessed cognitive change over time.

What it found

Fifty-five participants met the study’s definition of meaningful cognitive decline; 44 of them had progression independent of relapse or MRI activity. Higher lesion count and larger choroid plexus volume at diagnosis were associated with that outcome.

Limits and interpretation

This longitudinal observational study cannot show that either MRI marker causes decline or that acting on it prevents it. The cohort was relatively small and from one clinical setting. Independent, larger studies are needed before the markers guide individual prognosis.

This sourced news summary and translation were prepared with AI assistance. Source links, the news date and research limitations are disclosed; this is not a claim of independent medical expert review. News production method.

Sources

Research news is not medical advice or a recommendation to use a substance. Read findings in the context of the study design, participants and limitations. Editorial standards.

← All news