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Study design
The single-blind, multicentre LatAm-FINGERS trial randomized at-risk older adults in Latin America to a two-year structured multidomain program or a flexible multidomain intervention. Program components included physical activity, nutritional guidance, cognitive training and vascular-risk management. Outcome assessors were blinded.
Findings
The single-blind trial compared a structured multidomain program with a flexible multidomain intervention. The primary global-cognition score increased by 0.31 SD per year with the structured program and 0.20 SD per year with the flexible program (between-group difference 0.11 SD/year; 95% CI 0.06–0.15; p<0.0001). Outcome assessors were blinded. This was a modest test-score difference, not evidence that fewer participants developed dementia.
Limits and disclosures
The program combines several components, so the trial cannot isolate diet’s contribution. Participants and staff could not all be blinded, and the results do not establish prevention of dementia. The paper describes a multicentre randomized trial; individual benefit may vary.
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Sources
Research news is not medical advice or a recommendation to use a substance. Read findings in the context of the study design, participants and limitations. Editorial standards.
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